Search Dictionary
Definition of antagonistic
antagonistic
/ænˌtæɡ.əˈnɪs.tɪk/
an · tag · o · nis · tic
Adverb:antagonistically
antagonistic Lexical Profile
CEFR
C1
Grade
10
Tier
2
Usage
Top 10k
Syllables
5
antagonistic Game Scores & Validity
Scrabble US
Scrabble UK
WWF
Wordle Guess
• adjective
1
Showing or feeling active opposition, hostility, or animosity toward someone or something.
Example
"The spokesperson adopted an unnecessarily antagonistic tone when answering questions from the press."
2
Acting in opposition or counteracting the effect of another force, muscle, or chemical substance (in physiology, biochemistry, and pharmacology).
Example
"The biceps and triceps are an antagonistic pair of muscles that work opposite each other to move the forearm."
Synonyms
View all synonyms for antagonistic Antonyms
View all antonyms for antagonistic• Rhymes for antagonistic
• Nearby Words
Word Origin & Etymology
Derived from the Ancient Greek 'antagonistes' (opponent, rival), formed from 'anti-' (against) and 'agonizesthai' (to struggle or contend for a prize), from 'agon' (contest).
Cite this Entry
Wordmom. (2026). Definition of Antagonistic. In Wordmom Dictionary. Retrieved Nov 5, 2026, from https://wordmom.com/dictionary/antagonistic