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Definition of syphilis
syphilis
/ˈsɪf.ə.lɪs/
syph · i · lis
Plural:syphilises
•Adjective:syphilitic
syphilis Lexical Profile
CEFR
C1
Grade
10
Tier
2
Usage
Top 10k
Syllables
3
syphilis Game Scores & Validity
Scrabble US
Scrabble UK
WWF
Wordle Guess
• noun
1
A chronic, systemic bacterial disease transmitted primarily by sexual contact or from mother to fetus, caused by the spirochete Treponema pallidum and progressing through distinct stages from painless ulcers to severe neurological and cardiovascular damage if left untreated.
Example
"Before the discovery of penicillin in the twentieth century, syphilis was a widespread and often fatal medical condition."
Synonyms
View all synonyms for syphilis• Rhymes for syphilis
Word Origin & Etymology
Coined in 1530 by the Italian physician and poet Girolamo Fracastoro in his Latin poem 'Syphilis sive morbus gallicus' ('Syphilis, or the French Disease'), named after the protagonist Syphilus, a shepherd cursed with the illness by Apollo.
Usage Trend
Historical frequency of usage in published text.
180019102020
Data source: Google Books Ngram Viewer
Cite this Entry
Wordmom. (2026). Definition of Syphilis. In Wordmom Dictionary. Retrieved Nov 5, 2026, from https://wordmom.com/dictionary/syphilis