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Definition of prion

prion

/ˈpriː.ɑːn/
pri · on

Plural:prions
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prion Lexical Profile

prion Game Scores & Validity

• noun

1

An abnormal, infectious form of a cellular protein that lacks nucleic acid and causes fatal neurodegenerative diseases by inducing normal cellular proteins to misfold.

Example

"Researchers are actively studying how the prion responsible for variant Creutzfeldt-Jakob disease propagates in human brain tissue."


2

Any of several small seabirds of the genus Pachyptila, native to the southern oceans and characterized by a serrated bill used to filter zooplankton from seawater.

Example

"While sailing through the frigid Antarctic waters, the crew spotted a flock of prions skimming the surface of the ocean."

Synonyms
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• Rhymes for prion

Word Origin & Etymology

In biology, coined in 1982 by American neurologist Stanley B. Prusiner as a portmanteau of 'proteinaceous' and 'infectious', with the suffix '-on' added by analogy to 'virion'. In ornithology, it derives from the Ancient Greek 'priōn' (saw), referring to the serrated edges of the bird's bill.

Usage Trend

Historical frequency of usage in published text.

180019102020

Cite this Entry


Wordmom. (2026). Definition of Prion. In Wordmom Dictionary. Retrieved Oct 20, 2026, from https://wordmom.com/dictionary/prion
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