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Definition of mononucleosis

mononucleosis

/ˌmɑː.noʊˌnuː.kliˈoʊ.sɪs/
mo · no · nu · cle · o · sis
Plural:mononucleoses
•
Adjective:mononucleotic
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mononucleosis Lexical Profile

mononucleosis Game Scores & Validity

• noun

1

An acute infectious viral disease, most commonly caused by the Epstein-Barr virus, characterized by fever, sore throat, swollen lymph nodes, extreme fatigue, and an abnormally high number of mononuclear white blood cells.

Example

"The college student had to miss two weeks of classes after being diagnosed with infectious mononucleosis."

2

An abnormal hematological condition in which the bloodstream contains an unusually large proportion of mononuclear leukocytes (monocytes or lymphocytes).

Example

"The laboratory blood smear revealed marked mononucleosis, prompting further diagnostic testing for underlying viral infections."

Synonyms
View all synonyms for mononucleosis

• Rhymes for mononucleosis

• Nearby Words

monolithic
monologue
monongahela
mononucleosis
monoplane
monopod
monopolist

Word Origin & Etymology

Coined in the early 20th century from New Latin, combining 'mononuclear' (from Ancient Greek 'monos' meaning single and Latin 'nucleus' meaning kernel) with the medical suffix '-osis' denoting an abnormal condition or excess.

Cite this Entry

Wordmom. (2026). Definition of Mononucleosis. In Wordmom Dictionary. Retrieved Nov 5, 2026, from https://wordmom.com/dictionary/mononucleosis
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