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Definition of lesion
lesion
/ˈliː.ʒən/
le · sion
Plural:lesions
•Adjective:lesional
•Past Simple:lesioned
•Past Participle:lesioned
•Present Participle:lesioning
lesion Lexical Profile
CEFR
C1
Grade
10
Tier
2
Usage
Top 10k
Syllables
2
lesion Game Scores & Validity
Scrabble US
Scrabble UK
WWF
Wordle Guess
• noun
1
A localized region in an organ or tissue that has suffered structural damage through injury or disease, such as a wound, ulcer, abscess, or tumor.
Example
"The dermatologist examined the small skin lesion to determine whether a biopsy was necessary."
Synonyms
View all synonyms for lesion• verb
1
To cause or produce a localized structural injury or pathological change in an organ or tissue (especially in experimental neuroscience or surgery).
Example
"Researchers lesioned a specific pathway in the hippocampus to study its role in spatial memory."
Synonyms
View all synonyms for lesion Antonyms
View all antonyms for lesion• Rhymes for lesion
• Nearby Words
Word Origin & Etymology
Borrowed from Old French lesion, from Latin laesio ('an injury'), derived from the verb laedere ('to strike, hurt, or injure'). It shares its Latin root with 'collide' and 'elide'.
Cite this Entry
Wordmom. (2026). Definition of Lesion. In Wordmom Dictionary. Retrieved Nov 5, 2026, from https://wordmom.com/dictionary/lesion