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Definition of histamine
histamine
/ˈhɪs.tə.miːn/
his · ta · mine
Plural:histamines
•Adjective:histaminic
histamine Lexical Profile
CEFR
C1
Grade
10
Tier
2
Usage
Top 10k
Syllables
3
histamine Game Scores & Validity
Scrabble US
Scrabble UK
WWF
Wordle Guess
• noun
1
A nitrogenous organic compound released by mast cells and basophils during immune and allergic responses, which regulates physiological functions in the gut, dilates blood vessels, and acts as a neurotransmitter.
Example
"When the immune system detects pollen, it releases histamine, triggering symptoms such as sneezing and watery eyes."
• Rhymes for histamine
Word Origin & Etymology
Coined in the early 20th century as a blend of "histidine" (the amino acid from which it is derived, from Ancient Greek "histion" meaning "tissue") and "amine."
Cite this Entry
Wordmom. (2026). Definition of Histamine. In Wordmom Dictionary. Retrieved Nov 5, 2026, from https://wordmom.com/dictionary/histamine