Search Dictionary
Definition of endorphin

endorphin

/ɛnˈdɔːrfɪn/
en · dor · phin
Plural:endorphins
JUMP TO:

endorphin Lexical Profile

endorphin Game Scores & Validity

• noun

1

Any of a group of peptide hormones and neurotransmitters secreted within the brain and nervous system that bind to opiate receptors, reducing the perception of pain and promoting feelings of euphoria or well-being.

Example

"Vigorous aerobic exercise triggers the release of endorphins, which often produces a sense of calm and elation known as a runner's high."

• Rhymes for endorphin

• Nearby Words

endnote
endocortex
endodontist
endorphin
endorsable
endorse
endorsement

Word Origin & Etymology

Coined in 1975 by American neuroscientist Eric J. Simon as a blend of "endogenous" (originating within the body) and "morphine," referring to the peptide's natural pain-relieving properties.

Usage Trend

Historical frequency of usage in published text.

180019102020
Data source: Google Books Ngram Viewer

Cite this Entry

Wordmom. (2026). Definition of Endorphin. In Wordmom Dictionary. Retrieved Nov 5, 2026, from https://wordmom.com/dictionary/endorphin
Built for writers, students, and competitive word game players, Wordmom combines an uncluttered English dictionary and thesaurus with fast, pattern-based word finders so you can verify definitions, synonyms, and high-scoring tile plays in one place.
Word Games & Solvers
Word FinderScrabble Word FinderWords With Friends CheatWordle SolverAnagram Solver
Dictionary & Reference
DictionarySynonymsAntonymsWords
Community
Contact UsEditorial PolicyPrivacy PolicyTerms and Conditions
© 2016–2026 Wordmom Network. All rights reserved. Made with for word lovers everywhere.
Disclaimer: SCRABBLE® is a registered trademark. All intellectual property rights in and to the game are owned in the U.S.A. and Canada by Hasbro Inc., and throughout the rest of the world by J.W. Spear & Sons Limited of Maidenhead, Berkshire, England, a subsidiary of Mattel Inc. Mattel and Spear are not affiliated with Hasbro. Words With Friends® is a registered trademark of Zynga Inc. Wordle® is a registered trademark of The New York Times Company. Other referenced game titles and tournament lexicon codes (including NASPA NWL and WESPA/HarperCollins CSW) are trademarks of their respective owners. Wordmom is an independent reference utility for educational and entertainment purposes and is not affiliated with, sponsored by, or endorsed by Hasbro, Mattel, Spear, Zynga, The New York Times Company, NASPA, WESPA, or HarperCollins Publishers. All game names are referenced strictly under nominative fair use to indicate compatibility.