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Definition of efficacy

efficacy

/ˈɛf.ɪ.kə.si/
ef · fi · ca · cy

Adverb:efficaciously
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Plural:efficacies
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Adjective:efficacious
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efficacy Lexical Profile

efficacy Game Scores & Validity

• noun

1

The ability or capacity to produce a desired or intended result, especially under controlled or ideal conditions.

Example

"Researchers conducted a three-year clinical trial to evaluate the long-term efficacy of the new vaccine."

Synonyms
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Antonyms
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Word Nuance & Usage

In clinical and academic contexts, 'efficacy' specifically denotes how well an intervention performs under ideal, controlled conditions (such as a clinical trial), whereas 'effectiveness' measures how well it performs in real-world practice; it should also be distinguished from 'efficiency', which refers to achieving a result with minimal wasted effort or expense.

• Rhymes for efficacy

Word Origin & Etymology

Borrowed in the early 16th century from Latin efficacia, derived from efficax ('powerful, effectual'), from the verb efficere ('to accomplish, work out'), combining ex- ('out') and facere ('to make, do').

Cite this Entry


Wordmom. (2026). Definition of Efficacy. In Wordmom Dictionary. Retrieved Nov 5, 2026, from https://wordmom.com/dictionary/efficacy
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